NULLIPARITY, DELAYED CHILD BIRTH AND OBESITY: POTENTIAL RISK FACTORS FOR DEVELOPMENT OF UTERINE FIBROID IN SOUTH-SOUTH NIGERIA
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Abstract
Background: Causes of fibroid are still unknown. Despite series of cytogenetic investigations, the uncertainty remains as to the primary or secondary genetic changes and their impact on the initiation or promotion of fibroid development.
Purpose: To determine the effect of obesity, nulliparity and delayed child birth on the occurrence of uterine fibroid.
Materials and Methods: A prospective sonographic survey was carried out in a population of women in South-South region of Nigeria. Ultrasound scan was performed in 240 randomly selected women aged 20 – 45 years, presenting for scans at the time of study. Subjects’ ages and reproductive history were obtained to ascertain their parity status and ages at which parous women had their first children.
Results: Results showed a weak positive association (r = 0.1; p < 0.05) between uterine fibroid and delayed child birth and nulliparity at 31-35 years. A strong positive association (r = 0.9; p < 0.05) was observed at 36 – 45 years. There was no statistically significant association between low, normal and high body mass index with uterine fibroid; however, a significant association (r = 0.85; p < 0.05) was observed with obesity.
Conclusion: Delayed child birth and nulliparity after 36 years of age appeared to be the most potent risk factor for uterine fibroid in the population studied.
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Olotu, E.J., Osunwoke, E.A., Ugboma, H.A., Odu, K.N. Age prevalence of uterine fibroids in South-South Nigeria: A retrospective study. Science Research, 2008; 3(9):457–457.
Marshall, L.M., Spiegelman, D., Goldman, M.B., et al. Risk of uterine leiomyomata among premenopausal women in relation to body size and cigarette smoking. 2004.
Chiaffarino, F., Parazzini, F., La Vecchia, C., et al. Diet and uterine leiomyomas. Obstetrics & Gynecology, 1999; 94:395–396.
Crammer, S.F., Patel, A. Epidemiology of uterine leiomyomas with etiologic hypothesis. Rep. Med., 1992; 40:393–400.
Ezem, C., Otubu, K. Incidence of uterine leiomyomata among hysterectomy cases in Nigeria. 1981.
Gambone, K., Geto, E. Effect of leiomyoma on the menstrual cycle. Obstetrics & Gynecology, 1990; 81:885–891.
Gross, B.H., Silver, T.M., Jaffe, M.H. Sonographic features of leiomyomas: Analysis of 41 proven cases. Journal of Ultrasound in Medicine, 1983; 2:401.
Haney, S. Clinical decisions regarding leiomyomas. Environmental Health, 2000; S835–839.
Keith, D., Hilton, M., David, C. Ultrasound in Obstetrics and Gynaecology. Churchill Livingstone, 1993.
Kjeruff, et al. Hysterectomy confirmed diagnosis of fibroid in Black and White American women, 1996.
Lumbiganon, P. Risk factors for fibroid occurrence. 1996; 32:261–269.
Rosati, P., Bellati, U., Exacoustos, C., et al. Uterine myomas in pregnancy: Ultrasound study. 1989; 28:109–117.
Ross, R.K., Pike, M.C., Vessey, M.P., et al. Risk factors for uterine fibroid. BMJ Clinical Research, 2006; 293:359–363.
Sato, F., Nishi, M., Kudo, R., Miyake, H. Body fat distribution and uterine leiomyomas. Journal of Epidemiology, 1998; 8:176–180.
Shikora, S.A., Niloff, J.M., Nistrain, D.R. Relationship between obesity and uterine leiomyomas. Nature, 1991; 7:241–255.