HYPERSENSITIVITY REACTIONS TO UROGRAFIN (76%): A PILOT STUDY IN NORTHEAST NIGERIA
Main Article Content
Abstract
Background: Patients react to radiographic contrast media in diverse ways.
Objectives: To assess hypersensitivity reactions to Urografin contrast media among patients booked for contrast-enhanced computed tomography scans in a tertiary hospital in Nigeria.
Methods: A prospective, 30-minute observation of each of 30 patients who had administration of urografin 76% intravenously. They were observed from the point of administration to the end of the investigation. Observed clinical reactions were documented and results were presented in tables.
Results: Out of thirty patients, six patients (20%) had nausea which is termed as mild reaction. Four of them (13.3%) vomited, a condition considered as moderate reaction. Twenty (66.7%) did not present with any reaction to contrast within the study time frame.
Conclusion: Nausea and vomiting were reactions observed in the study. No severe hypersensitivity reaction among all the patients who participated in the study was recorded.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles in JRRS are published under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to Cite
References
Tubiana, M. (2008). Comment on computed tomography and radiation exposure. New England Journal of Medicine, 358(8), 852–853. https://doi.org/10.1056/NEJMc073513
Anderson, S. W., Soto, J. A., & Lucey, B. C. (2009). Abdominal 64-MDCT for suspected appendicitis: The use of oral and IV contrast material versus IV contrast material only. American Journal of Roentgenology, 193(5), 1282–1288. https://doi.org/10.2214/AJR.09.2336
Kepner, A. M., Bacasnot, J. V., & Stahlman, B. A. (2012). Intravenous contrast alone versus intravenous and oral contrast computed tomography for the diagnosis of appendicitis in adult emergency department patients. American Journal of Emergency Medicine, 30(9), 1765–1773. https://doi.org/10.1016/j.ajem.2012.02.011
Moradirizi, M., Mirhoseini, M., Khaledifar, A., Taheri, A., & Rezaee, A. (2016). Examining the effect of iodized contrast agent of coronary heart angiography in people without thyroid gland disorders. Bali Medical Journal, 5(3), 104–110.
Katayama, H., Yamaguchi, K., Kozuka, T., Takashima, T., Seez, P., & Matsuura, K. (1990). Adverse reactions to ionic and nonionic contrast media: A report from the Japanese Committee on Safety of Contrast Media. Radiology, 175, 621–628.
Luk, L., & Newhouse, J. H. (2016). Overestimating the risk of intravenous contrast medium–induced nephropathy: A pitfall in imaging the genitourinary system. Seminars in Roentgenology, 51(1), 12–16.
Wysowski, D. K., & Nourjah, P. (2006). Deaths attributed to X-ray contrast media on U.S. death certificates. American Journal of Roentgenology, 186(3), 613–615.
Maria, R., Wenzel, A., Maletzky, B., & Ternes, T. A. (2014). Removal of the iodinated X-ray contrast medium diatrizoate by anaerobic transformation. Environmental Science & Technology, 48(17), 10145–10154. https://doi.org/10.1021/es5014714
Pasternak, J. J., & Williamson, E. E. (2012). Clinical pharmacology, uses, and adverse reactions of iodinated contrast agents: A primer for the non-radiologist. Mayo Clinic Proceedings, 87(4), 390–402. https://doi.org/10.1016/j.mayocp.2012.01.012
Katzberg, R. W. (2008). Acute reactions to urographic contrast medium: Incidence, clinical characteristics, and relationship to history of hypersensitivity states—A commentary. American Journal of Roentgenology, 190, 1431–1432.
Bottinor, W., Polkampally, P., & Jovin, I. (2013). Adverse reactions to iodinated contrast media. International Journal of Angiology, 22(3), 149–154. https://doi.org/10.1055/s-0033-1348885
Chin, R., & Lee, B. Y. (2008). Principles and practice of clinical trial medicine (1st ed., pp. 39–71). Academic Press. ISBN: 9780080557939
Kobayashi, D., Takahashi, O., Ueda, T., Deshpande, G. A., Arioka, H., & Fukai, T. (2013). Risk factors for adverse reactions from contrast agents for computed tomography scans. BMC Medical Informatics and Decision Making, 13, 18. https://doi.org/10.1186/1472-6947-13-18
Persson, P. B. (2005). Contrast medium–induced nephropathy (Editorial). Nephrology Dialysis Transplantation, 20, 65–69.
Thomson, K. R., & Varma, D. K. (2010). Safe use of radiographic contrast media. Australian Prescriber, 33(1), 19–22.
Loh, S., Bagheri, S., Katzberg, R. W., Fung, M. A., & Li, C. (2010). Delayed adverse reaction to contrast-enhanced CT: A prospective single-center study comparison to control group without enhancement. Radiology, 255(3), 764–771.
Sutton, A. G. C., Finn, P., Grech, E. D., et al. (2001). Early and late reactions after the use of iopamidol 340, ioxaglate 320, and iodixanol 320 in cardiac catheterization. American Heart Journal, 141(4), 677–683.
Sutton, A. G. C., Finn, P., Campbell, P. G., et al. (2003). Early and late reactions following the use of iopamidol 340, iomeprol 350, and iodixanol 320 in cardiac catheterization. Journal of Invasive Cardiology, 15(3), 133–138.
From, A. M., Al Badarin, F. J., McDonald, F. S., Bartholmai, B. J., Cha, S. S., & Rihal, C. S. (2010). Iodixanol versus low-osmolar contrast media for prevention of contrast-induced nephropathy: Meta-analysis of randomized controlled trials. Circulation: Cardiovascular Interventions, 3(4), 351–358.
Andreucci, M., Solomon, R., & Tasanarong, A. (2014). Side effects of radiographic contrast media: Pathogenesis, risk factors, and prevention. BioMed Research International, 2014, Article ID 741018. https://doi.org/10.1155/2014/741018