Endometrial osseous metaplasia:2 case reports and literature review
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Abstract
Endometrial osseous metaplasia (EOM), sometimes called endometrial microcalcifications or endometrial calcinosis, is a rare pathological condition characterized by the presence of osseous tissues within the endometrium and a major cause of infertility and menorrhagia in women. The objective of the reports was to describe and report two cases with a brief review of literature in 24- and 25-year-old women in Jos, North Central Nigeria. The first case presented with the history of secondary infertility following a cesarean section, and the second presented with a history of recurrent miscarriages. Both cases were encountered and evaluated in a private healthcare facility in Jos between March and October 2025. Histopathological evaluation demonstrated the presence of mature osseous tissue interspersed with endometrial glands and proliferative endometrium. Serial sonograms consistently demonstrated a concentric and irregularly shaped hyperechogenic endometrial plate with posterior acoustic shadowing. These sonographic features are well characterized in literature for EOM. While ultrasound is a veritable tool for suggesting EOM, a definitive diagnosis is confirmed by a hysteroscopy and histopathological evaluation.
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